Tyrosinase ( the enzyme responsible for melanin formation) can be inactivated by chelating with its vital copper ion (Cu2+) and suppressing the tautomerization from Dopachrome to DHICA. Without copper ions, tyrosinase cannot activate tyrosine and melanin formation could be reduced.
Kojic acid is the one of the efficient tyrosinase competitors.
Kojic Acid has been used in Japan since 1988 and has extended into other parts of the world,. The word kojic acid is originated from koji, a by-product in the fermentation process of malting rice for use in the manufacturing of Japanese rice wine. However, kojic acid is an unstable ingredient in cosmetic formulations. Upon exposure to air or sunlight it can turn brown and lose its efficacy.
Many cosmetic companies use kojic dipalmitate as an alternative because it is more stable in formulations. However, kojic acid whitening skincare is not exist in market anymore after some controversial research has suggested that kojic acid may have carcinogenic properties in large doses in mice were found liver cancer.
philosophy
Many cosmetic companies use kojic dipalmitate as an alternative because it is more stable in formulations. However, kojic acid whitening skincare is not exist in market anymore after some controversial research has suggested that kojic acid may have carcinogenic properties in large doses in mice were found liver cancer.
philosophy
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